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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
22.73
Human Site:
T709
Identified Species:
33.33
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
T709
A
E
P
A
M
P
N
T
Y
G
V
E
P
L
P
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
T700
A
E
P
A
M
P
N
T
Y
G
V
E
P
L
P
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
H683
A
R
F
V
V
G
S
H
V
R
H
H
P
S
N
Dog
Lupus familis
XP_541736
1001
113024
T806
Q
E
P
A
M
P
N
T
Y
G
V
E
P
L
P
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
T709
L
E
P
A
M
P
N
T
Y
G
V
E
P
L
P
Rat
Rattus norvegicus
NP_001101343
905
102125
T710
T
E
P
A
M
P
N
T
Y
G
V
E
P
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
T716
P
E
P
A
L
P
N
T
Y
G
V
D
P
L
P
Chicken
Gallus gallus
NP_001006139
888
100332
V696
I
L
P
N
T
Y
G
V
E
P
L
P
Q
E
I
Frog
Xenopus laevis
P55861
886
100243
V694
A
L
P
N
T
F
G
V
E
A
L
P
Q
E
V
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
V688
V
L
P
N
T
F
D
V
P
P
I
P
Q
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
P693
L
K
T
V
D
E
I
P
Q
D
L
L
R
Q
Y
Honey Bee
Apis mellifera
XP_395109
1005
114136
D813
H
D
I
S
I
P
Q
D
L
L
K
K
Y
I
V
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
C590
V
T
Y
A
R
L
N
C
G
P
R
L
T
P
Q
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
K694
P
T
T
S
G
L
E
K
I
P
Q
E
L
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
G599
S
A
N
A
K
S
G
G
G
T
L
P
I
T
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
T697
E
A
D
E
R
L
A
T
F
V
V
D
S
H
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
13.3
93.3
N.A.
93.3
93.3
N.A.
80
6.6
13.3
6.6
N.A.
0
6.6
13.3
13.3
P-Site Similarity:
100
100
26.6
93.3
N.A.
93.3
93.3
N.A.
93.3
13.3
20
20
N.A.
13.3
40
13.3
20
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
13
0
50
0
0
7
0
0
7
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
7
0
7
7
0
7
0
13
0
0
0
% D
% Glu:
7
38
0
7
0
7
7
0
13
0
0
38
0
19
0
% E
% Phe:
0
0
7
0
0
13
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
7
19
7
13
38
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
7
0
0
7
7
0
7
0
% H
% Ile:
7
0
7
0
7
0
7
0
7
0
7
0
7
7
7
% I
% Lys:
0
7
0
0
7
0
0
7
0
0
7
7
0
0
7
% K
% Leu:
13
19
0
0
7
19
0
0
7
7
25
13
7
44
7
% L
% Met:
0
0
0
0
32
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
19
0
0
44
0
0
0
0
0
0
0
7
% N
% Pro:
13
0
57
0
0
44
0
7
7
25
0
25
44
7
38
% P
% Gln:
7
0
0
0
0
0
7
0
7
0
7
0
19
7
7
% Q
% Arg:
0
7
0
0
13
0
0
0
0
7
7
0
7
0
0
% R
% Ser:
7
0
0
13
0
7
7
0
0
0
0
0
7
7
0
% S
% Thr:
7
13
13
0
19
0
0
44
0
7
0
0
7
7
0
% T
% Val:
13
0
0
13
7
0
0
19
7
7
44
0
0
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
7
0
0
38
0
0
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _